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By ur-Rahman, Atta- Caldwell, Gary W. Choudhary, M. Iqbal

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In fact, it has been reported that peroxidation of membrane lipids in cells and tissues is known to produce various aldehydic compounds [41,42], seriously suspected to cause a variety of chronic diseases, including atherosclerosis [57], Alzheimer's disease [58], cataractogenesis [59], Parkinson's disease [60] and cancer [42]. 9) is a selenoenzyme that functions as an antioxidant by catalyzing the reduction of H2O2, lipid hydroperoxides and other organic GSTs in Drug Discovery and Development Frontiers in Drug Design & Discovery, 2009, Vol.

7). A: Organic isothiocyanates undergo enymatic conjugation with GSH to form dithiocarbamates. B: GSTs catalyze the attack of the GSH on the electrophilic sulfur atom of organic thiocyanates. 32 Frontiers in Drug Design & Discovery, 2009, Vol. 4 Skopelitou et al. 5. Sulfonamidase Activity The mechanism of sulfonamide cleavage by GST has been investigated using as a model substrate the PNU-109112, a potent HIV-1 protease inhibitor [10,11]. The mechanism of reaction, shown in Fig. (8), could involve initial GS- attack on either the sulfonyl S atom or the adjacent carbon atom in the cyanopyridine ring.

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