By Bhanu P. Chowdhary
Analysis of the equine genome began just over a decade in the past, culminating within the contemporary complete sequencing of the pony genome. the provision of the equine entire genome series represents the winning of entirety of a tremendous period of equine genome analysis, and the starting of a brand new period the place the series info will catalyze the advance of latest instruments and assets that would allow learn of various qualities which are economically very important and are major to equine future health and welfare.
Equine Genomics offers a well timed entire evaluate of equine genomic examine. Chapters element key accomplishments and the present kingdom of analysis, in addition to expecting attainable functions of genomic applied sciences to horse breeding, overall healthiness, and welfare. Equine Genomics gives you an international evaluation of the subject and is seamlessly edited through a number one equine genomics researcher.
Equine Genomics is an indispensible resource of knowledge for someone with an curiosity during this more and more vital box of analysis, together with equine genomic researchers, clinicians, animal technology execs and equine box veterinarians.Content:
Chapter 1 Defining the Equine Genome: The Nuclear Genome and the Mitochondrial Genome (pages 1–9): Bhanu P. Chowdhary
Chapter 2 Genetic Linkage Maps (pages 11–47): June Swinburne and Gabriella Lindgren
Chapter three actual and Comparative Maps (pages 49–71): Terje Raudsepp and Bhanu P. Chowdhary
Chapter four The Y?Chromosome (pages 73–92): Terje Raudsepp, Nandina Paria and Bhanu P. Chowdhary
Chapter five unforeseen Structural positive factors of the Equine significant Histocompatibility advanced (pages 93–101): Loren C. Skow and Candice L. Brinkmeyer?Langford
Chapter 6 meeting and research of the Equine Genome series (pages 103–111): Claire M. Wade
Chapter 7 Genomic instruments and assets: improvement and functions of an Equine SNP Genotyping Array (pages 113–124): Molly McCue and Jim Mickelson
Chapter eight sensible Genomics (pages 125–141): Stephen J. Coleman, Michael J. Mienaltowski and James N. MacLeod
Chapter nine Coat colour Genomics (pages 143–153): Samantha A. Brooks and Rebecca R. Bellone
Chapter 10 Genomics of pores and skin problems (pages 155–170): Amy E. younger, Stephen D. White and Danika L. Bannasvch
Chapter eleven Genomics of Muscle issues (pages 171–185): James R. Mickelson, Stephanie J. Valberg, Carrie J. Finno and Molly E. McCue
Chapter 12 Genomics of Skeletal problems (pages 187–198): Ottmar Distl
Chapter thirteen Genomics of replica and Fertility (pages 199–215): Terje Raudsepp, Pranab J. Das and Bhanu P. Chowdhary
Chapter 14 Genetics of Equine Neurologic disorder (pages 217–239): Carrie J. Finno and Monica Aleman
Chapter 15 Molecular Genetic checking out and Karyotyping within the Horse (pages 241–254): M. C. T. Penedo and Terje Raudsepp
Chapter sixteen Genomics of Laminitis (pages 255–264): Jim okay. Belknap
Chapter 17 Genomics of functionality (pages 265–283): Emmeline W. Hill, Lisa M. Katz and David E. MacHugh
Chapter 18 Genomics of the Circadian Clock (pages 285–309): Barbara A. Murphy
Chapter 19 Mitochondrial Genome: Clues concerning the Evolution of Extant Equids and Genomic variety of Horse Breeds (pages 311–321): Cynthia C. Steiner, Kateryna D. Makova and Oliver A. Ryder
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Additional info for Equine Genomics
Fayrer-Hosken, R. , Hurley, D. , & Heusner, G. L. (2008). Advancements in large animal embryo transfer and related biotechnologies. Reproduction in Domestic Animals, 43(3), 371–376. Scott, I. , & Long, S. E. (1980). An examination of chromosomes in the stallion (Equus caballus) during meiosis. Cytogenetics and Cell Genetics, 26(1), 7–13. Swinburne, J. , Leeb, T. et al. (2009). A whole-genome scan for recurrent airway obstruction in Warmblood sport horses indicates two positional candidate regions.
The breeds used in this pedigree were: Arabian, Thoroughbred, Welsh Cob, European Warmblood, and Icelandic Horse. utilized were, ﬁrst, the nonsurgical removal of equine conceptuses (Allen & Bracher 1992), and second, the generation of monozygotic twins via embryo micromanipulation (Allen & Pashen 1984). The resulting family was referred to as the Newmarket horse reference family. The equine conceptus is unusual in its late implantation, which does not occur until 37 days post-conception. The embryo is easily recoverable via uterine lavage using videoendoscopy until this time, and will yield 3–5 mg DNA on extraction.
The most common approaches for the construction of physical maps are in situ molecular hybridization to chromosomes leading to the development of cytogenetic maps, and genotyping markers on somatic cell and radiation hybrid panels, resulting in synteny and radiation hybrid (RH) maps. Additionally, highresolution physical maps can be generated by constructing contigs of overlapping large insert clones or by DNA ﬁngerprinting of entire genomic libraries. Finally, the ultimate physical map of any genomic region, chromosome, or the whole genome is the complete DNA sequence.