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By M. Ligumsky, D. Rachmilewitz (auth.), Keith Hillier (eds.)

The unique sequence, Advances in Prostaglandin study, edited by means of Sultan M. M. Karim, used to be released by means of MTP Press in 3 volumes in 1975 and 1976. a look at these books illustrates the growth that has been made due to the fact then. The thromboxanes have been pointed out two times (first booklet 1975) and prostacyclin now not as soon as (first booklet 1976); leukotrienes have been basically at the horizon. the fantastic iteration of study info within the final 10-15 years has given new, huge insights into many components, together with bronchial asthma, irritation, renaL cardiovascular and gastrointestinal ailments and in copy, and has led in a few situations to genuine scientific profit. This series,AdvancesinEicosanoidResearch, displays the present realizing of prostaglandins, thromboxanes and leukotrienes. the purpose is to supply an introductory history to every subject and the main updated info to be had. even if each one booklet stands on my own, the eicosanoids lower throughout many obstacles of their simple activities; chosen chapters from every one e-book within the sequence will offer illuminating and effective info for all readers as a way to increase their schooling and examine. within the construction of this sequence, i need to recognize with excitement my collaboration with editors and authors and the sufferer endeavours of Dr. Michael Brewis and the employees at MTP Press.

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Extra info for Eicosanoids and the Gastrointestinal Tract

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The formation of the other metabolites of arachidonic acid formed by the colonic mucosa and separated using this TLC system were also increased. The methodology can be utilized to determine the in vitro effects of drugs used clinically in the treatment of IBD on eicosanoid synthesis. The effects of sulphasalazine and its metabolites, 5-amino-salicylic acid (5-ASA) and sulphapyridine on [14 C)AA metabolism by human colonic mucosa have been investigated35 . 6. In these experiments, sulphasalazine inhibited the formation of TxB 2 .

138-165. (Academic Press) 6. Whittle. R. and Vane. R. (1983). Prostacyclin. thromboxanes. and prostaglandins actions and roles in the gastrointestinal tract. In ]erzy-Glass. B. and Sherlock. P. ) Progress in Gastroenterology. pp. 3-30. (New York: Grune and Stratton) 7. ]. and Bukhave. K. (1979). Prostaglandins and chronic diarrhoea: clinical aspects. Scand. ]. • 14. Suppl. 53. 73-78 8. Rachmilewitz. O. (1980). Prostaglandins and diarrhoea. Dig. Dis. Sci.. 25. 897-899 9. Samuelsson. • Borgeat. P..

In ]erzy-Glass. B. and Sherlock. P. ) Progress in Gastroenterology. pp. 3-30. (New York: Grune and Stratton) 7. ]. and Bukhave. K. (1979). Prostaglandins and chronic diarrhoea: clinical aspects. Scand. ]. • 14. Suppl. 53. 73-78 8. Rachmilewitz. O. (1980). Prostaglandins and diarrhoea. Dig. Dis. Sci.. 25. 897-899 9. Samuelsson. • Borgeat. P.. Hammarstrom. S. C (1980). Leukotrienes: a new group of biologically active compounds. In Samuelsson. B.. RamwelL P. and Paoletti. R. ) Adv. Prostagl. Thrombox.

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