Download Coronary Tone in Ischemic Heart Disease by W. Kupper (auth.), Wolfram Kupper MD, Rex N. MacAlpin MD, PDF

By W. Kupper (auth.), Wolfram Kupper MD, Rex N. MacAlpin MD, Walter Bleifeld MD (eds.)

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10mm (mean ± SO) [14] . Geometric considerations: dynamic vascular wall thickening Quantitation of vasomotion observed by angiography is limited to comparing the luminal diameter in two or more states of vasomotion. Because we cannot see the 30 arterial wall itself, we do not always appreciate the changes occurring in it that produce the variations in luminal dimensions, we call 'vasomotion' [11,15,16]. The elementary geometric principle used to predict the narrowing expected at a lesion site, given the severity ofthe lesion and the degree of vasoconstriction of the adjacent normal segment, is shown in Figures 2, 3 and 4.

Dr. Serruys: We have tested the system in perspex models starting under static and dynamic flow conditions and in collaboration with Dr. Rafflenbeul we compared post-mortem lesions with in vivo coronary angiograms and it was shown that the resolution of the system is excellent. Dr. Dickenson: I just wonder whether there is another factor that comes in. I remember that before electromagnetic flow meters were used, one of the ways to measure flow was to make a constriction on a tube and then measure the pressure difference between pre- and poststenotic area.

8. Chierchia S: The role of alpha-adrenergic receptors in the pathogenesis of coronary spasm. Clin Cardiol 6:496-500, 1983. 52 9. Feigl EO: Coronary physiology. Physiol Rev 63:1-205,1983. 10. Holtz J, Busse R, Giesler M: Flow-dependent dilation of canine epicardial coronary arteries in vivo and in vitro: Mediated by the endothelium. Naunyn-Schmiedebergs Arch Pharmacol 322:R44, 1983. 11. Holtz J, Giesler M, Bassenge E: Two dilatory mechanisms of antianginal drugs on epicardial coronary arteries in vivo: indirect, flow-dependent, endothelium-mediated dilation and direct smooth muscle relaxation.

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