By Ulf J. Eriksson (auth.), Lois Jovanovic M.D. (eds.)
As I learn this special quantity on diabetes and being pregnant edited by way of Lois Jovanovic, i used to be struck by means of topics that run all through those accumulated chapters. First, this quantity presents a superb review of prior difficulties, current administration, and destiny demanding situations offered through dia betes in being pregnant. Orury's distinctive, longitudinal adventure with diabetes iIi being pregnant presents the reader with a massive evaluation, as does Coetzee's dialogue of gestational diabetes. present problems-deter mining the etiology and prevention of congenital malformations in babies of diabetic moms (10M), evaluate of antepartum fetal , administration of pregnant sufferers with diabetic retinopathy, popularity of thyroid disorder within the pregnant diabetic girl, and knowing the multitude of metabolic sequelae saw within the 10M-are completely reviewed. eventually, very important concerns for destiny remedy and ther apy corresponding to the difference of the fetal pancreas to the disordered intra uterine surroundings usually noticeable in maternal diabetes, using fetal pan creatic tissue for transplantation, the applying of workout within the administration of the pregnant girl with diabetes, and the long term con sequences for the 10M supply a thrilling glimpse into the longer term. the second one very important subject that emerges is the serious function the matter of diabetes in being pregnant has performed in our figuring out of maternal and fetal body structure. scientific observations supported by way of simple examine have emphasised the function of fetal fuels in teratogenesis.
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Extra resources for Controversies in Diabetes and Pregnancy
Brownscheidle CM, Davies DL (1981) Diabetes in pregnancy: a preliminary study of the pancreas, placenta and malformations in the BB Wi star rat. Placenta 33 [Suppl]:203-16. 30. Baker L, Egler JM, Klein SM, Goldman AS (1981) Meticulous control of diabetes during organogenesis prevents congenital lumbosacral defects in rats. Diabetes 30:955-59. 31. Eriksson UJ, Dahlstrom E, Larsson KS, Hellerstrom C (1982) Increased incidence of congenital malformations in the offspring of diabetic rats and their prevention by maternal insulin therapy.
Trace Metals Recent investigations suggest a relation between diabetic teratogenesis and trace metal disorders. Manifestly diabetic rats displayed disturbances of both maternal and fetal trace metal levels, in particular a reduced fetal zinc concentration, which was refractory to zinc treatment of the mother (35,87). These ideas are strengthened by the findings of decreased transport of zinc in late and early diabetic rat gestation (93). When nondiabetic rats of this malformation-prone substrain were fed a specially prepared diet poor in zinc, the fetuses exhibited similar degrees of zinc deficiency.
In: Sutherland HW, Stowers JM (eds) Carbohydrate Metabolism in Pregnancy and the Newborn. Churchill Livingstone, Edinburgh, pp 150-151. 59. Cella SG, Locatelli V, de Gennaro V, Puggioni R, Pintor C, MOller EE (\985) Human pancreatic growth hormone (GH)-releasing hormone stimulates GH synthesis and release in infant rats. An in vivo study. Endocrinology 116:574577. 60. Domenech M, Gruppuso PA, Susa JB, Schwartz T (1985) Induction in utero of hepatic glucose 6-phosphatase by fetal hypoinsulinemia.