By Anna Porwit, Jeffrey McCullough, Wendy N Erber MD DPhil FRCPA FRCPath
Already a regular reference paintings within the box, the recent variation of Blood and Bone Marrow Pathology comprises the most recent WHO type schemes and the most recent ancillary diagnostic strategies in immunohistochemistry and molecular biology so that it will offer a finished, good balanced and authoritative advisor to the translation and analysis of neoplastic and non-neoplastic illnesses of blood and bone marrow. The textual content is lavishly illustrated with prime quality color pictures that exhibit the proper pathological,features and immunohistochemical and molecular markers. The textual content encompasses a well-organized method that comes with useful suggestions and clues to aid steer clear of pitfalls and to make sure optimum diagnosisChapters were absolutely rewritten and a few new chapters were further specifically on myeloid malignancies, according to the WHO 2008 type All chapters were revised to include new facets of molecular biology and up to date relating move cytometry diagnostics Greater emphasis on sensible diagnostic points for all problems fresh editorial and contributing writer crew. complete on-line textual content via professional seek advice. complete downloadable photo BankAlready a regular reference paintings within the box, the hot version of Blood and Bone Marrow Pathology accommodates the most recent WHO class schemes and the most recent ancillary diagnostic concepts in immunohistochemistry and molecular biology with a purpose to supply a accomplished, good balanced and authoritative consultant to the translation and analysis of neoplastic and non-neoplastic ailments of blood and bone marrow. The textual content is lavishly illustrated with prime quality color pictures that reveal the appropriate pathological,features and immunohistochemical and molecular markers. The textual content encompasses a well-organized strategy that comes with useful tips and clues to aid stay away from pitfalls and to make sure optimum prognosis
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Additional resources for Blood and Bone Marrow Pathology: Expert Consult: Online and Print, 2nd Edition
Promyelocytes and more mature cells are acid phosphatase-positive; the immature cells have stronger positivity than the mature ones. Segmented neutrophil granulocytes show weak to strong staining for alkaline phosphatase and a few metamyelocytes stain weakly. Antigen expression Multipotent myeloid stem cells are CD34+, CD38+ and CD33+. Several antigens change their expression intensity during granulopoiesis, especially CD13, CD11b, and CD16. 2 and FCM findings illustrated in Fig. 5,6,29,30 CD13 is expressed at high levels on CD34+ stem cells and CD117+ precursors (promyelocytes).
16,17 Erythroid progenitor cells that do not develop successfully into erythrocytes undergo apoptosis and are phagocytosed by BM macrophages. The loss of potential erythrocytes, or ‘ineffective’ erythropoiesis, is small in normal BM but substantial in certain anemias. Regulation of erythropoiesis A key factor determining the rate of red cell production is the glycoprotein hormone erythropoietin (EPO) which, in the adult, is produced mainly by the peritubular cells of the kidney. 18 An important effect of EPO is, therefore, to maintain the viability and proliferation of erythroid progenitor cells, by preventing apoptosis.
The neutrophil myelocyte is smaller than the promyelocyte and has a greater volume of predominantly acidophilic cytoplasm. 1). The nucleus is rounded, oval, flattened on one side or slightly indented (Fig. 9C), has coarsely granular chromatin and usually lacks a nucleolus. Neutrophil metamyelocytes are smaller than myelocytes and have a C-shaped nucleus with greater nuclear chromatin condensation than the myelocyte nucleus. The cytoplasm is acidophilic and contains numerous neutrophilic granules but few or no azurophilic granules.