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By A. N. Davison

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1974). Biochim. Biophys. Acta 361, 241-247. M a d e n , Â. Å. H . (1971). Progr. Biophys. Mol. Biol. 22, 127-177. Martin, Ô. , Wool, I. G. and Castle, J. J. (1971). Methods Enzymol. 20, 417-429. Noll, H . (1969). In " T e c h n i q u e s in Protein Biosynthesis" (P. N . Campbell and J. R. Sargent, eds), Vol. 2. Academic Press, L o n d o n and N e w York, p p . 101-179. Perry, R. , Kelley, D . E. and L a T o r r e , J. (1974). J. Mol. Biol. 82, 315-331. Pinder, J. C , Staynov, D . Z. and Gratzer, W .

1 9 6 7 ; Pala y an d Chan-Palay , 1974). Further , behavioura l studie s ar e b e c o m i n g increasingl y importan t in th e elucidatio n of th e function s of th e n e r v o u s s y s t e m , an d m e t h o d s ar e particularl y well d e v e l o p e d for th e evaluatio n of m o t o r skills , in w h i c h th e c e r e b e l l u m play s a n importan t role . T h e onl y efferen t n e u r o n e s in th e cerebella r corte x ar e th e Purkinj e cells, an d the y ar e forme d on da y 11—13 in th e m o u s e e m b r y o (Mial e an d S i d m a n , 1961).

1976). I t is als o foun d in th e forebrai n s u b e p e n d y m a l layer . D e g e n e r a t i n g cells h a v e b e e n show n to be postmitotic ; m a c r o m o l e c u l e synthesi s h o w e v e r is probabl y derange d befor e cells w h i c h ar e destine d t o di e ente r thei r las t S phas e (Polla k an d Fallon , 1974). I t ha s b e e n calculate d ( L e w i s , 1975) tha t onl y abou t 3 % of n e w l y forme d n e u r o n e s (cerebellum ) or neurogli a (forebrain ) ar e lost throug h thi s norma l degenerativ e process .

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