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By Gerd Plewig MD, Albert M. Kligman MD, PhD (auth.)

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Extra info for Acne: Morphogenesis and Treatment

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20 Generally speaking, there is a good correlation between gland size and secretory activity. Facial oiliness is associated with large glands. Children have tiny glands and the casual lipid levels on the surface are thus very low. This rule, however, has qualifications. After middle age, especially in men, the facial glands tend to get larger, often becoming quite huge after 65 years of age. However, sebum production does not increase and indeed usually decreases. This is clearly a consequence of decreased mitotic activity.

It turns out that this takes two to three weeks, depending of course on the size of the gland (cells have further to go in big glands). Replacement of the living portion of the facial epidermis is much shorter, closer to a week. Elsewhere than on the head, the back for instance, the viable epidermis is replaced in about fourteen days, to which must be added about another two weeks for the cells to move 21 through the horny layer, a month in all for renewal of the entire epidermis. , production of lipid cells is increased.

Derm. 56, 127-131 (1971). : The skin microflora in acne vulgaris. J. invest. Derm. 62, 37-41 (1974). : Corynebacterium acnes and other anaerobic diphtheroids from human skin. J. Med. Microbiol. 7, 349-357 (1974). : Microbiology of comedones in acne vulgaris. J. invest. Derm. 60, 80-83 (1973). : Characteristics of the extracellular lipases from Corynebacterium acnes and Staphylococcus epidermidis. J. invest. Derm. 63, 231-238 (1974). : Dermal hypersensitivity of patients with acne vulgaris to Corynebacterium aenes.

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