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Although these analyses did not achieve statistical significance, for participants 4 – 6 years old, we observed a numeric difference toward a larger increase in BMI on the daily dose compared to the weekend dose during the first 3 months of treatment. In the 7- to 10-year-old participants, there was a visual numeric difference, which while not significant, suggested a greater increase in BMI on the daily dose. 4) Weekend dose Daily dose No. (%) Mean (SD) No. 06 Mobility function scale Abbreviations: FEV1 ϭ forced expiratory volume in 1 minute; FVC ϭ forced vital capacity; MIP ϭ maximum inspiratory pressure; MMT ϭ manual muscle testing; MVV ϭ maximal voluntary ventilation; QMT ϭ quantitative muscle testing.

Lotze serves on a scientific advisory board for Opexa Therapeutics. Dr. ; holds stock in Johnson & Johnson; is director of the Washington University Neuromuscular Clinical Laboratory which performs antibody testing and muscle and nerve pathology analysis, procedures for which the Washington University Neurology Department bills; may accrue revenue on patents re: TS-HDS antibody, GALOP antibody, GM1 ganglioside antibody, and Sulfatide antibody; has received license fee payments from Athena Diagnostics, Inc.

9. 10. 11. 12. 13. 14. 15. 16. 17. 18. 19. 20. 21. 22. 452 Griggs RC, Moxley RT III, Mendell JR, et al. Prednisone in Duchenne dystrophy: a randomized, controlled trial defining the time course and dose response: Clinical Investigation of Duchenne Dystrophy Group. Arch Neurol 1991;48:383–388. Griggs RC, Moxley RT III, Mendell JR, et al. Duchenne dystrophy: randomized, controlled trial of prednisone (18 months) and azathioprine (12 months). Neurology 1993; 43:520 –527. Manzur AY, Kuntzer T, Pike M, Swan A.

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